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Proceedings Paper

Polymer microstructures for cellular growth studies
Author(s): Luisa Filipponi; Kristi L. Hanson; Abraham Phillip Lee; Dan V. Nicolau
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Paper Abstract

The understanding and control of cell growth in confined microenvironments has application to a variety of fields including cell biosensor development, medical device fabrication, and pathogen control. While the majority of work in these areas has focused on mammalian and bacterial cell growth, this study reports on the growth behavior of fungal cells in three-dimensionally PDMS microenvironments of a scale similar to that of individual hyphae. Confinement was found to affect filament branching rate and angle. Overall, fungal hyphae demonstrate much more coordinated behavior during confinement than observed during growth on simple planar unconfined substrates. The remarkable difference of fungal growth behaviour observed in the PDMS microenvironments compared to open, unrestricted environments suggests that three-dimensional microstructures could be used to control and alter fungal motility.

Paper Details

Date Published: 16 February 2005
PDF: 7 pages
Proc. SPIE 5651, Biomedical Applications of Micro- and Nanoengineering II, (16 February 2005); doi: 10.1117/12.584143
Show Author Affiliations
Luisa Filipponi, Swinburne Univ. of Technology (Australia)
CRC for Microtechnology (Australia)
Kristi L. Hanson, Swinburne Univ. of Technology (Australia)
Abraham Phillip Lee, Univ. of California/Irvine (United States)
Dan V. Nicolau, Swinburne Univ. of Technology (Australia)

Published in SPIE Proceedings Vol. 5651:
Biomedical Applications of Micro- and Nanoengineering II
Dan V. Nicolau, Editor(s)

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