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Proceedings Paper

Emission lifetimes of human hemoglobin computed from the atomic coordinates
Author(s): Zygmunt Gryczynski; Todd Tenenholz; Enrico Bucci
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Paper Abstract

Using the Forster equations we have estimated the rate of energy transfer from tryptophans to hemes in hemoglobin. We computed the orientation factors and the consequent transfer rates from the crystallographic coordinates of human oxy- and deoxyhemoglobin. The intrasubunit distances between hemes and tryptophans allow lifetimes between 5 and 15 ps per each ns of tryptophan lifetime. Lifetimes of several hundred ps would be allowed by the intersubunit distances, however, these distances become operative only when one heme per tetramer does not accept transfer. If more than one heme per tetramer does not function as an acceptor, lifetimes of several ns would be allowed.

Paper Details

Date Published: 1 April 1992
PDF: 6 pages
Proc. SPIE 1640, Time-Resolved Laser Spectroscopy in Biochemistry III, (1 April 1992); doi: 10.1117/12.58248
Show Author Affiliations
Zygmunt Gryczynski, Univ. of Maryland School of Medicine (United States)
Todd Tenenholz, Univ. of Maryland School of Medicine (United States)
Enrico Bucci, Univ. of Maryland School of Medicine (United States)


Published in SPIE Proceedings Vol. 1640:
Time-Resolved Laser Spectroscopy in Biochemistry III
Joseph R. Lakowicz, Editor(s)

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