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Proceedings Paper

Network dynamics of cultured hippocampal neurons in a multi-electrode array
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Paper Abstract

The neurons in dissociation culture autonomously re-organized their functional neuronal networks, after the process for elongating neurites and establishing synaptic connections. The spatio-temporal patterns of activity in the networks might be a reflection of functional neuron assemblies. The functional connections were dynamically modified by synaptic potentiation and the process may be required for reorganization of the functional group of neurons. Such neuron assemblies are critical for information processing in brain. To visualize the functional connections between neurons, we have analyzed the autonomous activity of synaptically induced action potentials in the living neuronal networks on a multi-electrode array, using "connection map analysis" that we developed for this purpose. Moreover, we designed aan original wide area covering electrode array and succeeded in recording spontaneous action potentials from wider area than commercial multi electrode arrays.

Paper Details

Date Published: 16 February 2005
PDF: 11 pages
Proc. SPIE 5651, Biomedical Applications of Micro- and Nanoengineering II, (16 February 2005); doi: 10.1117/12.582427
Show Author Affiliations
Takahisa Taguchi, National Institute of Advanced Industrial Science and Technology (Japan)
Suguru N. Kudoh, National Institute of Advanced Industrial Science and Technology (Japan)
Japan Science and Technology Agency (Japan)


Published in SPIE Proceedings Vol. 5651:
Biomedical Applications of Micro- and Nanoengineering II
Dan V. Nicolau, Editor(s)

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