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Proceedings Paper

Ultrasensitive detection and manipulation of biomolecules
Author(s): Andrew A. Berlin; Xing Su
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Paper Abstract

Intel's Precision Biology research effort is working to combine Intel's expertise in nanotechnology with aspects of biology and medicine to create highly sensitive instrumentation for biomolecular analysis. The ability to manipulate, detect, and identify biological molecules at ultra-low concentrations is important for applications ranging from whole-genome DNA sequencing to protein-based early disease detection. In this paper we describe our work to develop a molecular labeling system based on Surface-Enhanced Raman Spectroscopy (SERS), to enable highly sensitive protein detection. We also present a variety of techniques our team has developed for microfluidic transport and identification of single molecules in solution.

Paper Details

Date Published: 8 December 2004
PDF: 11 pages
Proc. SPIE 5591, Lab-on-a-Chip: Platforms, Devices, and Applications, (8 December 2004); doi: 10.1117/12.581957
Show Author Affiliations
Andrew A. Berlin, Intel Corp. (United States)
Xing Su, Intel Corp. (United States)

Published in SPIE Proceedings Vol. 5591:
Lab-on-a-Chip: Platforms, Devices, and Applications
Linda A. Smith; Daniel Sobek, Editor(s)

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