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Proceedings Paper

Light-drive biomedical micro-tools and biochemical IC chips fabricated by 3D micro/nano stereolithography
Author(s): Koji Ikuta; Shoji Maruo; Tadahiro Hasegawa; Suenobu Itho; Hayato Korogi; Atsushi Takahashi
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Paper Abstract

New concept of micro/nano tools working in water solutuon has been proposed by the author. A real three dimensional micro fabrication process using photo curable polymer named "micro/nano stereolithography" has been also developed by the author's group. The latest version of this process achieved 100 nm in 3D resolution and freely movable micro/nano mechanism are easily fabricated within 20 min. Nano tweezers and nano needle with two degrees of freedom were successfully fabricated without any assembly process. Cell and delicate biological materials can be remotely handled with neither any micro actuators nor lead wire. It was verified that this light-driven micro tool has precise force control with 10 FtN. These light-driven micro tools contribute to cellular biology as well as medical tools. The second application of microstereolithography is the biochemical IC chips for both micro chemical analysis and synthesis. Unlike conventional "lab. on a chip" and "micro total analysis system" (micro-TAS), our biochemical IC has micro pumps and active valves in one chip. Users can construct their own micro chemical device by themselves. The advanced biochemical IC chip-set for "on chip cell-free protein synthesis" has been prototyped and verified experimentally. A luminous enzyme of fire fly so called "Luciferase" and useful bio-marker protein "GFP" were synthesized successfully. According to above results, the biomchemical IC chips will be useful to "Order-made medicine" in near future.

Paper Details

Date Published: 25 October 2004
PDF: 15 pages
Proc. SPIE 5604, Optomechatronic Micro/Nano Components, Devices, and Systems, (25 October 2004); doi: 10.1117/12.581900
Show Author Affiliations
Koji Ikuta, Nagoya Univ. (Japan)
Shoji Maruo, Nagoya Univ. (Japan)
Tadahiro Hasegawa, Nagoya Univ. (Japan)
Suenobu Itho, Nagoya Univ. (Japan)
Hayato Korogi, Nagoya Univ. (Japan)
Atsushi Takahashi, Nagoya Univ. (Japan)


Published in SPIE Proceedings Vol. 5604:
Optomechatronic Micro/Nano Components, Devices, and Systems
Yoshitada Katagiri, Editor(s)

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