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Proceedings Paper

Scanning force microscopy of circular DNA and chromatin in air and propanol
Author(s): James Vesenka; Helen G. Hansma; Cristina Siegerist; Giuliano Siligardi; Eric Schabtach; Carlos J. Bustamante
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Paper Abstract

High resolution electron micrographs of microtips show nanometer surface irregularities. We propose that the lower contact forces, and consequent greater sensitivity, from imaging in propanol enables small biomolecules to be imaged at higher resolution by these 'nanotips'. However, larger molecules, such as the nucleosomes of chromatin, are still imaged by the bulk of the tip and no improvement of resolution is obtained.

Paper Details

Date Published: 1 May 1992
PDF: 11 pages
Proc. SPIE 1639, Scanning Probe Microscopies, (1 May 1992); doi: 10.1117/12.58189
Show Author Affiliations
James Vesenka, Univ. of Oregon (United States)
Helen G. Hansma, Univ. of California/Santa Barbara (United States)
Cristina Siegerist, Univ. of Oregon (United States)
Giuliano Siligardi, Birkbeck College (United Kingdom)
Eric Schabtach, Univ. of Oregon (United States)
Carlos J. Bustamante, Univ. of Oregon (United States)

Published in SPIE Proceedings Vol. 1639:
Scanning Probe Microscopies
Srinivas Manne, Editor(s)

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