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Proceedings Paper

Novel fluorescence-based integrated sensor for chemical and biological agent detection
Author(s): Greg Frye-Mason; Martin Leuschen; Lara Wald; Kateri Paul; Lawrence F. Hancock; Steve Fagan; Justin Krouse; Kira D. Hutchinson
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Paper Abstract

There is a renewed interest in the development of chemical and biological agent sensors due to the increased threat of weapons deployment by terrorist organizations and rogue states. Optically based sensors address the needs of military and homeland security forces in that they are reliable, rapidly deployed, and can provide continuous monitoring with little to no operator involvement. Nomadics has developed optically based chemical weapons sensors that utilize reactive fluorescent chromophores initially developed by Professor Tim Swager at MIT. The chromophores provide unprecedented sensitivity and selectivity toward toxic industrial chemicals and certain chemical weapon agents. The selectivity is based upon the reactivity of the G-class nerve agents (phosphorylation of acetylcholinesterase enzyme) that makes them toxic. Because the sensor recognizes the reactivity of strong electrophiles and not molecular weight, chemical affinity or ionizability, our system detects a specific class of reactive agents and will be able to detect newly developed or modified agents that are not currently known. We have recently extended this work to pursue a combined chemical/biological agent sensor system incorporating technologies based upon novel deep ultraviolet (UV) light emitting diodes (LEDs) developed out of the DARPA Semiconductor UV Optical Sources (SUVOS) program.

Paper Details

Date Published: 29 December 2004
PDF: 11 pages
Proc. SPIE 5617, Optically Based Biological and Chemical Sensing for Defence, (29 December 2004); doi: 10.1117/12.581275
Show Author Affiliations
Greg Frye-Mason, Nomadics, Inc. (United States)
Martin Leuschen, Nomadics, Inc. (United States)
Lara Wald, Nomadics, Inc. (United States)
Kateri Paul, Nomadics, Inc. (United States)
Lawrence F. Hancock, Nomadics, Inc. (United States)
Steve Fagan, Nomadics, Inc. (United States)
Justin Krouse, Nomadics, Inc. (United States)
Kira D. Hutchinson, Nomadics, Inc. (United States)


Published in SPIE Proceedings Vol. 5617:
Optically Based Biological and Chemical Sensing for Defence
John C. Carrano; Arturas Zukauskas, Editor(s)

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