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Proceedings Paper

Differential phase surface plasmon resonance biosensors
Author(s): Ho Pui Ho; Shu Yuen Wu; Chinlon Lin
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Paper Abstract

An optical differential phase surface plasmon resonance (SPR) technique capable of performing refractive index measurement with accuracy in the order of 5 x 10-8 is presented. The system makes use of the s-polarization as the reference beam to interfere with the p-polarization, of which the phase has close relationship with the change of surface plasmon resonance conditions at the sensor surface. The extraction of phase information is achieved by performing fringe analysis on the interference pattern captured by a digital oscilloscope. Results obtained from monitoring BSA (Bovine Serum Albumin) binding reaction with BSA antibodies demonstrated that our setup has a sensitivity limit of 7.4 ng ml-1.

Paper Details

Date Published: 18 January 2005
PDF: 8 pages
Proc. SPIE 5630, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II, (18 January 2005); doi: 10.1117/12.581160
Show Author Affiliations
Ho Pui Ho, Chinese Univ. of Hong Kong (Hong Kong China)
Shu Yuen Wu, Chinese Univ. of Hong Kong (Hong Kong China)
Chinlon Lin, Chinese Univ. of Hong Kong (Hong Kong China)


Published in SPIE Proceedings Vol. 5630:
Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II
Britton Chance; Mingzhe Chen; Arthur E. T. Chiou; Qingming Luo, Editor(s)

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