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Proceedings Paper

Optical coherence tomography: potentialities in clinical practice
Author(s): Elena Zagaynova; Natalia D. Gladkova M.D.; Andrey Shakhov; Anna Terentjeva; Ludmila B. Snopova M.D.; Irina A. Kuznetzova M.D.; Olga Streltzova; Natalia M. Shakhova M.D.; Vladislav A. Kamensky; Grigory V. Gelikonov; Valentin M. Gelikonov; Roman V. Kuranov; Alex Myakov
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Paper Abstract

Clinical studies using OCT involved 2000 patients in various fields of medicine such as gastroenterology, urology, laryngology, gynecology, dermatology, stomatology, etc. Layered high-contrast images were typical for benign epithelial conditions. OCT distinguish in mucosae: epithelium, connective tissue layer, and smooth-muscle layer. Various benign processes occurring in mucosa manifest in OCT images as changes in the epithelial height, scattering properties and the course of the basement membrane. Lack of the layered structural pattern is the main criterion for dysplastic / malignant images. In clinic: OCT data may be critical for choosing a tissue site for excisional biopsy, OCT can detect tumor borders and their linear dimensions, OCT can be used to plan a resection line in operations and to control adequacy of resection, to monitor whether reparative processes are timely and adequate. OCT sensitivity of the uterine cervix, urinary bladder and larynx is 82, 98, 77%, respectively, specificity - 78, 71, 96%, diagnostic accuracy - 81, 85, 87% with significantly good agreement index of clinicians kappa - 0.65, 0.79, 0.83 (confidence intervals: 0.57-0.73; 0.71-0.88; 0.74-0.91). Error in detection of high grade dysplasia and microinvasive cancer is 21.4% in average. Additional modification of OCT (cross-polarisation OCT, OCM), development of the procedure (biotissue compression, application of chemical agents) can improve the specificity and sensitivity of traditional modality.

Paper Details

Date Published: 20 August 2004
PDF: 12 pages
Proc. SPIE 5474, Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V, (20 August 2004); doi: 10.1117/12.580771
Show Author Affiliations
Elena Zagaynova, Nizhny Novgorod State Medical Academy (Russia)
Natalia D. Gladkova M.D., Nizhny Novgorod State Medical Academy (Russia)
Andrey Shakhov, Nizhny Novgorod State Medical Academy (Russia)
Anna Terentjeva, Nizhny Novgorod State Medical Academy (Russia)
Ludmila B. Snopova M.D., Nizhny Novgorod State Medical Academy (Russia)
Irina A. Kuznetzova M.D., Nizhny Novgorod Regional Hospital (Russia)
Olga Streltzova, Nizhny Novgorod Regional Hospital (Russia)
Natalia M. Shakhova M.D., Institute of Applied Physics (Russia)
Vladislav A. Kamensky, Institute of Applied Physics (Russia)
Grigory V. Gelikonov, Institute of Applied Physics (Russia)
Valentin M. Gelikonov, Institute of Applied Physics (Russia)
Roman V. Kuranov, Institute of Applied Physics (Russia)
Alex Myakov, Institute of Applied Physics (Russia)

Published in SPIE Proceedings Vol. 5474:
Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V
Valery V. Tuchin, Editor(s)

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