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Proceedings Paper

Miniature biochip system for bioenvironmental applications
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Paper Abstract

An integrated multi-functional biochip based on integrated circuit complementary metal oxide semiconductor (CMOS) sensor array for use in medical diagnostics and pathogen detection has been described. The usefulness and potential of the biochip as a rapid, inexpensive screening tool for detection of bioenvironmental pathogens will be demonstrated. Detection of aerosolized spores was achieved by coupling the miniature system to a portable bioaerosol sampler, and the performance of the antibody-based recognition and enzyme amplification method was evaluated. The bioassay performance was found to be compatible with the air sampling device, and the enzymatic amplification was found to be an attractive amplification method for detection of low spore concentrations. The combined portable bioaerosol sampler and miniature biochip system detected 100 B. globigii spores, corresponding to 17 aerosolized spores/L of air.

Paper Details

Date Published: 7 December 2004
PDF: 7 pages
Proc. SPIE 5586, Advanced Environmental, Chemical, and Biological Sensing Technologies II, (7 December 2004); doi: 10.1117/12.580126
Show Author Affiliations
Musundi B. Wabuyele, Oak Ridge National Lab. (United States)
Fei Yan, Oak Ridge National Lab. (United States)
M. E. Martin, Oak Ridge National Lab. (United States)
Guy D. Griffin, Oak Ridge National Lab. (United States)
David L. Stokes, Oak Ridge National Lab. (United States)
Dimitra N. Stratis-Cullum, Army Research Lab. (United States)
Joel Mobley, Oak Ridge National Lab. (United States)
Arpad A. Vass, Oak Ridge National Lab. (United States)
Tuan Vo-Dinh, Oak Ridge National Lab. (United States)


Published in SPIE Proceedings Vol. 5586:
Advanced Environmental, Chemical, and Biological Sensing Technologies II
Tuan Vo-Dinh; Gunter Gauglitz; Robert A. Lieberman, Editor(s)

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