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Proceedings Paper

Photoaggregation of crystallins (main proteins of eye lens) under the effect of XeCl laser radiation
Author(s): Lev V. Soustov; Evgeny V. Chelnokov; Nikita M. Bityurin; A. L. Kiselev; V. V. Nemov; Yu. V. Sergeev; Michail A. Ostrovsky
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Paper Abstract

UV light is one of primary factors associated with cataract formation in the eye lens. α-, β-, γ-Crystallins maintain lens transparency, and damage to these proteins plays a major role in cataract formation. The effect of XeCl laser radiation (308 nm) on βL-crystallin solution is studied. The strong dependence of protein aggregation kinetics on both laser fluence (w) and repetition rate (F) is investigated. The kinetics features are similar to those of carbonic anhydrase photoaggregation studied previously.

Paper Details

Date Published: 15 July 2004
PDF: 6 pages
Proc. SPIE 5506, Nonresonant Laser-Matter Interaction (NLMI-11), (15 July 2004); doi: 10.1117/12.579988
Show Author Affiliations
Lev V. Soustov, Institute of Applied Physics (Russia)
Evgeny V. Chelnokov, Institute of Applied Physics (Russia)
Nikita M. Bityurin, Institute of Applied Physics (Russia)
A. L. Kiselev, Institute of Applied Physics (Russia)
V. V. Nemov, Institute of Epidemiology and Microbiology (Russia)
Yu. V. Sergeev, National Eye Institute, National Institutes of Health (United States)
Michail A. Ostrovsky, Institute of Biochemical Physics (Russia)

Published in SPIE Proceedings Vol. 5506:
Nonresonant Laser-Matter Interaction (NLMI-11)
Mikhail N. Libenson, Editor(s)

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