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Proceedings Paper

Hemolysis induced by psoralen previously photo-oxidized in ethanol or aqueous solutions
Author(s): Alla A. Kyagova; Mekhriban I. Ismailova; Mikhail V. Malakhov; Alexander Ya. Potapenko
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Paper Abstract

Hemolytic effects of psoralen previously photooxidized (366 nm) in ethanol and aqueous solutions were investigated on human erythrocytes. Photooxidation of psoralen in ethanol or aqueous solutions gives a mixture of hemolysins, some of which spontaneously degrade during about 0.5 h of storage with a loss of hemolytic activity whilst others retain their activity during several days of storage. On exposure of psoralen to UVA irradiation in ethanol solutions, water-degradable hemolysins along with not degradable by water are produced. Reciprocity law of the fluence rate and time of irradiation is not fulfilled for the hemolysins production; they are more efficiently produced at high fluence rate of ultraviolet.

Paper Details

Date Published: 20 August 2004
PDF: 9 pages
Proc. SPIE 5474, Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V, (20 August 2004); doi: 10.1117/12.578949
Show Author Affiliations
Alla A. Kyagova, Russian State Medical Univ. (Russia)
Mekhriban I. Ismailova, N. Narimanov Azerbiijan Medical Univ. (Azerbaijan)
Mikhail V. Malakhov, Russian State Medical Univ. (Russia)
Alexander Ya. Potapenko, Russian State Medical Univ. (Russia)

Published in SPIE Proceedings Vol. 5474:
Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V
Valery V. Tuchin, Editor(s)

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