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Proceedings Paper

Parallel fluorescence correlation spectroscopy with a fully integrated single photon 2x2 detector array made with conventional CMOS technology
Author(s): Alexandre Serov; Michael Goesch; Alexis Rochas; Hans Blom; Tiemo Anhut; Pierre-Andre Besse; Radivoje S. Popovic; Theo Lasser; Rudolf Rigler
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Paper Abstract

We present multipoint Fluorescence Correlation Spectroscopy (FCS) experiments with a fully integrated Complementary Metal Oxide Semiconductor (CMOS) single photon 2x2 detector array. Multifocal excitation was achieved with a diffractive optical element (DOE). Special emphasis was put on parallelization of the total system. In particular the performance of the single-photon CMOS detector was investigated and compared to a state-of-the art single-photon detecting module (actively quenched avalanche photo diode) by measurements on free diffusing molecules at different concentrations. The potential of our new technique for high throughput FCS based systems is discussed.

Paper Details

Date Published: 20 August 2004
PDF: 11 pages
Proc. SPIE 5474, Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V, (20 August 2004); doi: 10.1117/12.578934
Show Author Affiliations
Alexandre Serov, Swiss Federal Institute of Technology (Switzerland)
Michael Goesch, Swiss Federal Institute of Technology (Switzerland)
Karolinska Institutet (Sweden)
Alexis Rochas, Swiss Federal Institute of Technology (Switzerland)
Hans Blom, Royal Institute of Technology (Sweden)
Tiemo Anhut, Swiss Federal Institute of Technology (Switzerland)
Pierre-Andre Besse, Swiss Federal Institute of Technology (Switzerland)
Radivoje S. Popovic, Swiss Federal Institute of Technology (Switzerland)
Theo Lasser, Swiss Federal Institute of Technology (Switzerland)
Rudolf Rigler, Karolinska Institutet (Sweden)
Gnothis SA (Switzerland)


Published in SPIE Proceedings Vol. 5474:
Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V
Valery V. Tuchin, Editor(s)

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