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Proceedings Paper

Noncontact diffuse optical tomography
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Paper Abstract

We present a simple and novel theoretical approach for modeling the intensity distribution from an arbitrarily shaped turbid volume in a non-contact geometry by considering diffuse light propagation in free-space. Optical tomography of turbid media has so far been limited by systems that require fixed geometries or fiber measurements. This novel theory is validated with experiments for a diffusive volume of known geometry in a non-contact situation, both with and without the presence of an embedded absorber. We also present a system that records non-contact optical measurements from diffuse media of arbitrary shapes and retrieves the three-dimensional surface information of the diffuse medium. This approach offers significant experimental simplicity and yields high-information content datasets. The performance of this novel tomographic approach is demonstrated with experimental reconstructions of phantoms. Finally, the implications of this new formulation in the context of optical tomography in turbid media are discussed.

Paper Details

Date Published: 20 August 2004
PDF: 9 pages
Proc. SPIE 5474, Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V, (20 August 2004); doi: 10.1117/12.578917
Show Author Affiliations
Jorge Ripoll, Foundation for Research and Technology-Hellas (Greece)
Ralf B. Schulz, Ctr. for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School (United States)
Vasilis Ntziachristos, Ctr. for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 5474:
Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V

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