Share Email Print
cover

Proceedings Paper

Noninvasive glucose sensing in scattering media using OCT, PAS, and TOF techniques
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

In this paper, optical measurement techniques, which enable non-invasive measurement, are superimposed to glucose sensing in scattering media. Used measurement techniques are Optical Coherence Tomography (OCT), Photoacoustic spectroscopy (PAS) and laser pulse Time-of-Flight (TOF) measurement using a streak camera. In parallel with measurements, a Monte-Carlo (MC) simulation models have been developed. Experimental in vitro measurements were performed using Intralipid fat emulsion as a tissue simulating phantom for OCT and TOF measurements. In PAS measurements, a pork meat was used as a subject but also preliminary in vivo measurements were done. OCT measurement results show that the slope of the OCT signal's envelope changes as a function of glucose content in the scattering media. TOF measurements show that the laser pulse full width of half maximum (FWHM) changes a little as function of glucose content. An agreement with MC-simulations and measurements with Intralipid was also found. Measurement results of PAS technique show that changes in glucose content in the pork meat tissue can be measured. In vivo measurements with a human volunteer show that other factors such as physiological change, blood circulation and body temperature drift may interfere the PA response of glucose.

Paper Details

Date Published: 20 August 2004
PDF: 9 pages
Proc. SPIE 5474, Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V, (20 August 2004); doi: 10.1117/12.578321
Show Author Affiliations
Erkki Alarousu, Univ. of Oulu (Finland)
Jukka T. Hast, Univ. of Oulu (Finland)
Matti T. Kinnunen, Univ. of Oulu (Finland)
Mikhail Yu. Kirillin, M.V. Lomonosov Moscow State Univ. (Russia)
Risto A. Myllyla, Univ. of Oulu (Finland)
Jerzy Plucinski, Gdansk Univ. of Technology (Poland)
Alexey P. Popov, M.V. Lomonosov Moscow State Univ. (Russia)
Alexander V. Priezzhev, M.V. Lomonosov Moscow State Univ. (Russia)
Tuukka Prykari, Univ. of Oulu (Finland)
Juha Saarela, Univ. of Oulu (Finland)
Zuomin Zhao, Univ. of Oulu (Finland)


Published in SPIE Proceedings Vol. 5474:
Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V
Valery V. Tuchin, Editor(s)

© SPIE. Terms of Use
Back to Top