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Proceedings Paper

Ultrahigh-resolution endoscopic optical coherence tomography
Author(s): Yu Chen; Paul R. Herz; Pei-Lin Hsiung; Aaron D. Aguirre; Hiroshi Mashimo; Saleem Desai; Macos Pedrosa; Amanda Koski; Joseph M. Schmitt; James G. Fujimoto
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Paper Abstract

Early detection of gastrointestinal cancer is essential for the patient treatment and medical care. Endoscopically guided biopsy is currently the gold standard for the diagnosis of early esophageal cancer, but can suffer from high false negative rates due to sampling errors. Optical coherence tomography (OCT) is an emerging medical imaging technology which can generate high resolution, cross-sectional images of tissue in situ and in real time, without the removal of tissue specimen. Although endoscopic OCT has been used successfully to identify certain pathologies in the gastrointestinal tract, the resolution of current endoscopic OCT systems has been limited to 10 - 15 m for clinical procedures. In this study, in vivo imaging of the gastrointestinal tract is demonstrated at a three-fold higher resolution (< 5 m), using a portable, broadband, Cr4+:Forsterite laser as the optical light source. Images acquired from the esophagus, gastro-esophageal junction and colon on animal model display tissue microstructures and architectural details at high resolution, and the features observed in the OCT images are well-matched with histology. The clinical feasibility study is conducted through delivering OCT imaging catheter using standard endoscope. OCT images of normal esophagus, Barrett's esophagus, and esophageal cancers are demonstrated with distinct features. The ability of high resolution endoscopic OCT to image tissue morphology at an unprecedented resolution in vivo would facilitate the development of OCT as a potential imaging modality for early detection of neoplastic changes.

Paper Details

Date Published: 18 January 2005
PDF: 8 pages
Proc. SPIE 5630, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II, (18 January 2005); doi: 10.1117/12.577171
Show Author Affiliations
Yu Chen, Massachusetts Institute of Technology (United States)
Paul R. Herz, Massachusetts Institute of Technology (United States)
Pei-Lin Hsiung, Massachusetts Institute of Technology (United States)
Aaron D. Aguirre, Massachusetts Institute of Technology (United States)
Hiroshi Mashimo, Veterans Administration Medical Ctr., Harvard Medical School (United States)
Saleem Desai, Veterans Administration Medical Ctr., Harvard Medical School (United States)
Macos Pedrosa, Veterans Administration Medical Ctr., Harvard Medical School (United States)
Amanda Koski, LightLab Imaging Inc. (United States)
Joseph M. Schmitt, LightLab Imaging Inc. (United States)
James G. Fujimoto, Massachusetts Institute of Technology (United States)


Published in SPIE Proceedings Vol. 5630:
Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II
Britton Chance; Mingzhe Chen; Arthur E. T. Chiou; Qingming Luo, Editor(s)

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