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Proceedings Paper

Analysis of time evolution of fluorescence and absorption spectra of camptothecins
Author(s): Blanka Ziomkowska; Stefan Kruszewski; Ryszard Siuda; Michal Cyrankiewicz
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Paper Abstract

Camptothecins, fluorescent anticancer agents, exhibit at neutral and physiological pH changes over time in absorption and fluorescence spectra. Analysis of these changes is a subject of this paper. Factor analysis of fluorescence spectra enabled to determine the kinetics of hydrolysis of camptothecin, i.e. the rate of converting of biologically active lactone form into inactive carboxylate. Obtained results are compared with HPLC data.

Paper Details

Date Published: 26 August 2004
PDF: 7 pages
Proc. SPIE 5566, Optical Security and Safety, (26 August 2004); doi: 10.1117/12.577162
Show Author Affiliations
Blanka Ziomkowska, Univ. of Technology and Agriculture (Poland)
Stefan Kruszewski, Univ. of Technology and Agriculture (Poland)
Ludwik Rydygier Medical Univ. (Poland)
Ryszard Siuda, Univ. of Technology and Agriculture (Poland)
Michal Cyrankiewicz, Univ. of Technology and Agriculture (Poland)


Published in SPIE Proceedings Vol. 5566:
Optical Security and Safety
Zbigniew Jaroszewicz; Ewa Powichrowska; Mariusz Szyjer, Editor(s)

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