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Proceedings Paper

UPT-based biosensor and its application
Author(s): Yongkai Zhao; Lei Zhou; Huijie Huang; Ruifu Yang; Lihua Huang; Bingqiang Ren; Jian Lu; Xiangzhao Wang
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Paper Abstract

An up-converting phosphor technology-based biosensor (UPT-based biosensor) has been developed for immunoassay using Up-converting phosphor (UCP) as the biological marker. The UPT system has realized quantitative detection and has good ability to meet the need of some emergencies. High sensitivity (nanogram/ml), good linear response characteristics and an excellent correlation (R2greater than or equal to 0.95) have been verified by quantitative detection results. The sensitivity of the UPT-based biosensor is better than that of the indirect hemagglutination test in the practical application. All the results are comparable with that obtained by Western Blot detection.

Paper Details

Date Published: 18 January 2005
PDF: 11 pages
Proc. SPIE 5630, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II, (18 January 2005); doi: 10.1117/12.577006
Show Author Affiliations
Yongkai Zhao, Shanghai Institute of Optics and Fine Mechanics, CAS (China)
Lei Zhou, Institute of Microbiology and Epidemiology, Academy of Military Sciences (China)
Huijie Huang, Shanghai Institute of Optics and Fine Mechanics, CAS (China)
Ruifu Yang, Institute of Microbiology and Epidemiology, Academy of Military Sciences (China)
Lihua Huang, Shanghai Institute of Optics and Fine Mechanics, CAS (China)
Bingqiang Ren, Shanghai Institute of Optics and Fine Mechanics, CAS (China)
Jian Lu, Shanghai Institute of Optics and Fine Mechanics, CAS (China)
Xiangzhao Wang, Shanghai Institute of Optics and Fine Mechanics, CAS (China)


Published in SPIE Proceedings Vol. 5630:
Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II
Britton Chance; Mingzhe Chen; Arthur E. T. Chiou; Qingming Luo, Editor(s)

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