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Proceedings Paper

Optical properties of native and coagulated human liver tissues at argon ion laser -- an in vitro study using the double-integrating-sphere technique
Author(s): Huajian Wei; Da Xing; Guoyong Wu; Huaimin Gu; Jianjun Lu; Xingyan Shen; Ying Jin
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Paper Abstract

We examine the optical properties of native and coagulated human liver tissues in vitro at four different wavelengths of argon ion laser, 476.5, 488, 496.5 and 514.5 nm, and the differences in the optical parameters of the tissues between 630nm and 790nm. The optical properties, μa, μs and g, of liver tissue were determined by measuring the diffuse reflectance, diffuse transmission and collimated transmission in a double integrating sphere set-up, and the inverse adding-doubling algorithm was used to calculate the optical properties from the measurements. The investigative results showed that there were significant differences respectively in the absorption coefficients, scattering coefficients and anisotropy factors between native and coagulated human liver tissues at the same laser wavelength (P<0.01), these large differences of the absolute values in optical properties indicate that there were large differences in compositions and structures between both, and large differences in compositions and structures induce large differences in absorption and scattering properties between both, and these differences vary with a change of laser wavelength. The scattering coefficients for per tissue type exceed the absorption coefficients by at least one order of magnitude. Hence the conclusions may be helpful to diagnostics and therapeutic applications in liver tissue.

Paper Details

Date Published: 18 January 2005
PDF: 7 pages
Proc. SPIE 5630, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II, (18 January 2005); doi: 10.1117/12.576323
Show Author Affiliations
Huajian Wei, South China Normal Univ. (China)
Da Xing, South China Normal Univ. (China)
Guoyong Wu, First Affiliated Hospital of Zhongshan Univ. (China)
Huaimin Gu, South China Normal Univ. (China)
Jianjun Lu, First Affiliated Hospital of Zhongshan Univ. (China)
Xingyan Shen, South China Normal Univ. (China)
Ying Jin, South China Normal Univ. (China)


Published in SPIE Proceedings Vol. 5630:
Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II
Britton Chance; Mingzhe Chen; Arthur E. T. Chiou; Qingming Luo, Editor(s)

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