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Proceedings Paper

Nanopatterned structures for biomolecular analysis toward genomic and proteomic applications
Author(s): Chia-Fu Chou; Jian Gu; Qihuo Wei; Yingjie Liu; Ravi Gupta; Takeyoshi Nishio; Frederic Zenhausern
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Paper Abstract

We report our fabrication of nanoscale devices using electron beam and nanoimprint lithography (NIL). We focus our study in the emerging fields of NIL, nanophotonics and nanobiotechnology and give a few examples as to how these nanodevices may be applied toward genomic and proteomic applications for molecular analysis. The examples include reverse NIL-fabricated nanofluidic channels for DNA stretching, nanoscale molecular traps constructed from dielectric constrictions for DNA or protein focusing by dielectrophoresis, multi-layer nanoburger and nanoburger multiplets for optimized surface-plasma enhanced Raman scattering for protein detection, and biomolecular motor-based nanosystems. The development of advanced nanopatterning techniques promises reliable and high-throughput manufacturing of nanodevices which could impact significantly on the areas of genomics, proteomics, drug discovery and molecular clinical diagnostics.

Paper Details

Date Published: 19 January 2005
PDF: 10 pages
Proc. SPIE 5592, Nanofabrication: Technologies, Devices, and Applications, (19 January 2005); doi: 10.1117/12.574872
Show Author Affiliations
Chia-Fu Chou, Arizona State Univ. (United States)
Jian Gu, Arizona State Univ. (United States)
Qihuo Wei, Arizona State Univ. (United States)
Yingjie Liu, Arizona State Univ. (United States)
Ravi Gupta, Arizona State Univ. (United States)
Takeyoshi Nishio, Arizona State Univ. (United States)
Frederic Zenhausern, Arizona State Univ. (United States)

Published in SPIE Proceedings Vol. 5592:
Nanofabrication: Technologies, Devices, and Applications
Warren Y-C. Lai; Stanley Pau; O. Daniel Lopez, Editor(s)

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