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Proceedings Paper

Intercalation between antitumor anthracyclines and DNA as probed by resonance and surface-enhanced Raman spectroscopy
Author(s): G. Smulevich; A. R. Mantini; M. Casu; M. P. Marzocchi
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Paper Abstract

The antiturnor anthracyclincs, idarubicin (IDA ), adrianiycin (ADM), epirubicin (EPI), carminomycin (CAR) and 1 1-deoxycarminornycin (DCM), whose siructural formula includes a substituted hydroxyanthraquirionc chrornophore and a sugar residue, form intercalation complexes with DNA. The stacking interaction between the chromophore and the base-pairs of DNA gives rise to noticeable ciTects on resonance Raman (RR) and surface-enhanced resonance Raman (SERRS) scattering as well as on the absorption (ABS), its second derivative (D2) and fluorescence emission (FEM) spectra.

Paper Details

Date Published: 1 May 1991
PDF: 3 pages
Proc. SPIE 1403, Laser Applications in Life Sciences, (1 May 1991); doi: 10.1117/12.57339
Show Author Affiliations
G. Smulevich, Univ. di Firenze (Italy)
A. R. Mantini, Univ. di Firenze (Italy)
M. Casu, Univ. di Firenze (Italy)
M. P. Marzocchi, Univ. di Firenze (Italy)

Published in SPIE Proceedings Vol. 1403:
Laser Applications in Life Sciences

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