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Proceedings Paper

High-power UV laser photolysis of nucleosides: final product analysis
Author(s): Dimitar A. Angelov; M. Berger; J. Cadet; Jean-Pierre Ballini; E. Keskinova; Paul Vigny
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Paper Abstract

Biophotonic excitation of purine and pyrimidine nucleobases becomes of increasingly importance as the laster intensity increases. Under these conditions the overall energy absorbed is much higher than the threshold energy required to generate pyrimidine and purine cathion radicals estimated to lies iin the 5-5.5 eV range (1). It is now communly accepted that the cathion radical is the primary damaging species generated upon two-quantum laser photolysis of nucleic acids derivatives. The chemistry of pyrimidine and purine cathion radicals in aqueous solutions has not been well udnerstood until recently. Two major exception delt with the initial chemical reaction of photo and ratioation - induced radical cation in low temperature thymine and thymidine - 5 - phosphate (2, 3) and at room temperature where the pyrimidine radical cathions were generated through an electron transfer reaction to photoexcited mendione in a triplet state.

Paper Details

Date Published: 1 May 1991
PDF: 3 pages
Proc. SPIE 1403, Laser Applications in Life Sciences, (1 May 1991); doi: 10.1117/12.57289
Show Author Affiliations
Dimitar A. Angelov, Institute of Solid State Physics (Bulgaria)
M. Berger, Lab. de Chimie (France)
J. Cadet, Lab. de Chimie (France)
Jean-Pierre Ballini, Institut Curie (France)
E. Keskinova, Institute of Solid State Physics (Bulgaria)
Paul Vigny, Institut Curie (France)

Published in SPIE Proceedings Vol. 1403:
Laser Applications in Life Sciences
Sergei A. Akhmanov; Marina Yu. Poroshina, Editor(s)

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