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Proceedings Paper

Generation of free radicals in high-intensity laser photolysis of organic microcyclic compounds: time-resolved spectroscopy and EPR study
Author(s): Dimitar A. Angelov; Ts. Gantchev; G. Grabner; N. Getoff; E. Keskinova; Maria Shopova
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Paper Abstract

Photochemistry can be used as a tool to investigate biological processes. Various natural compounds and phototherapeutic agents including llavin , psoralen , hematopor phyrin and phtalocyanine derivatives have been shown to oxydize purine components upon exposure to near - UV and visible light. It is usually assumed that it is the sensitizer in its triplet state which is the reactive species in photooxidation reactions either via an electron or hydragen atom transfer Ctype ID or via singlet oxygen and superoxide anion generation (type II) . It is currently accepted that superoxide radicals can generate hydroxyl COH ) radicals which are known to be the mai n DNA - damagirig speci es . Recenti y the use of photoserisi ti zed reactions as a tool of probing biomolecular structures and processess has been reviewed Cl - 3).

Paper Details

Date Published: 1 May 1991
PDF: 3 pages
Proc. SPIE 1403, Laser Applications in Life Sciences, (1 May 1991); doi: 10.1117/12.57288
Show Author Affiliations
Dimitar A. Angelov, Institute of Solid State Physics (Bulgaria)
Ts. Gantchev, National Ctr. of Oncology (Bulgaria)
G. Grabner, Univ. Wien (Austria)
N. Getoff, Univ. Wien (Austria)
E. Keskinova, Institute of Solid State Physics (Bulgaria)
Maria Shopova, Institute of Organic Chemistry (Bulgaria)

Published in SPIE Proceedings Vol. 1403:
Laser Applications in Life Sciences
Sergei A. Akhmanov; Marina Yu. Poroshina, Editor(s)

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