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Proceedings Paper

Optical coherence tomography imaging of structural components of the respiratory tract
Author(s): Suzanne C. Whiteman; Ying Yang; D. Gey van Pittius; Yonghong He; M. A. Spiteri; Ruikang K. Wang
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Paper Abstract

For optimal curative treatment and the prevention of metastasis, it is critical that premalignant lesions are detected as early as possible. However, current diagnostic methods for human airways do not possess sufficient resolution and tissue penetration depth to detect these aberrations. Therefore it is necessary to develop safe, reproducible imaging techniques with high spatial resolution. In this study, optical coherence tomography (OCT) was used to obtain cross sectional images of porcine respiratory tract tissue. OCT images were compared to parallel conventional histological sections. Our objective was to establish whether OCT differentiates the microstructural layers of the respiratory tract. These data demonstrate that OCT can characterize the multilayered structure of the airways, with a depth of up to 2 mm and a 10 μm spatial resolution. The subtle structural differences between trachea, main bronchus and tertiary bronchus were clearly identifiable. The epithelium, sub-epithelial tissues and cartilage were individually defined. In addition, the relative thickness of the structural components was comparable to histological sections. These data suggest that OCT is a highly feasible diagnostic tool, which requires further exploration for early detection of human airway pathology.

Paper Details

Date Published: 29 July 2004
PDF: 6 pages
Proc. SPIE 5486, ALT'03 International Conference on Advanced Laser Technologies: Biomedical Optics, (29 July 2004); doi: 10.1117/12.572000
Show Author Affiliations
Suzanne C. Whiteman, Keele Univ. (United Kingdom)
Ying Yang, Keele Univ. (United Kingdom)
D. Gey van Pittius, Univ. Hospital of North Staffordshire (United Kingdom)
Yonghong He, Cranfield Univ. (United Kingdom)
M. A. Spiteri, Keele Univ. (United Kingdom)
Ruikang K. Wang, Cranfield Univ. (United Kingdom)

Published in SPIE Proceedings Vol. 5486:
ALT'03 International Conference on Advanced Laser Technologies: Biomedical Optics
Ruikang K. Wang; Jeremy C. Hebden; Alexander V. Priezzhev; Valery V. Tuchin, Editor(s)

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