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Proceedings Paper

The influence of tissue optical properties on imaging performance of optoacoustic tomography
Author(s): Yingjie Liu; Yixiong Su; Fan Zhang; Ruikang K. Wang; Jianquan Yao
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Paper Abstract

Recent progress in optoacoustic tomography has shown its enormous potential in biomedical imaging of biological samples in vivo. The greatest advantage in this imaging modality is that it can offer the imaging contrast comparable to the optical techniques and the imaging resolution similar to the ultrasonic techniques. However, its sectioning capability is largely dependent on the scattering properties of the targeted subject. Therefore, the understanding of how the tissue optical properties affect the imaging performance of optoacoustic tomography would be important. In this paper, we systematically investigate the influence of absorption and scattering coefficients of tissue on the optoacoustic imaging resolution, depth and contrast. In addition, we also investigate the influence of spreading photon diffusion in the tissue on its sectioning capability. In the experiments, tissue phantoms were constructed with a range of optical properties. We used the intralipid solution to control the scattering properties, and the indocynane green to control the absorption property of the phantom. The result shows that the scattering coefficient is a major factor that affects the imaging depth and imaging contrast. It also influences greatly the thickness of tomographic imaging slice due to the light broadening inside tissue caused by the scattering property.

Paper Details

Date Published: 18 January 2005
PDF: 7 pages
Proc. SPIE 5630, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II, (18 January 2005); doi: 10.1117/12.571923
Show Author Affiliations
Yingjie Liu, Tianjin Univ. (China)
Yixiong Su, Tianjin Univ. (China)
Fan Zhang, Tianjin Univ. (China)
Ruikang K. Wang, Tianjin Univ. (China)
Cranfield Univ. at Silsoe (United Kingdom)
Jianquan Yao, Tianjin Univ. (China)

Published in SPIE Proceedings Vol. 5630:
Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II
Britton Chance; Mingzhe Chen; Arthur E. T. Chiou; Qingming Luo, Editor(s)

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