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Proceedings Paper

Qualitative optical fiber laser induced fluorescence spectroscopy for earlier cancer diagnosis
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Paper Abstract

Laser-induced fluorescence (LIF) is an accurate, sensitive and rapid method for the diagnosis of a normal and malignant tissue. In this paper, an optical fiber sensor was developed to enhance spectral difference between the normal and malignant tissue with sensor optimization to improve the accuracy of cancer diagnosis. This instrument incorporated a pulsed laser operating at 355 nm (frequency triple Nd:YAG and Q-switched Nd:YAG pump dye laser) with bifurcated optical fiber to allow illumination of tissue and collection of fluorescence with a single fiber. Using the laser excitation, the detection of the fluorescence signal from the tissue was performed almost instantaneously. A sufficient fluorescence contrast (of the order of more than 22.22 times) for malignant versus normal tissue was obtained. The results of our approach were compared with histopathology results and indicated excellent agreement in the classification of normal and malignant tissue.

Paper Details

Date Published: 14 December 2004
PDF: 6 pages
Proc. SPIE 5589, Fiber Optic Sensor Technology and Applications III, (14 December 2004); doi: 10.1117/12.571497
Show Author Affiliations
Chan Kyu Kim, Mississippi State Univ. (United States)
Sunil K. Khijwania, Indian Institute of Technology-Guwahati (India)
Jagdish P. Singh, Mississippi State Univ. (United States)


Published in SPIE Proceedings Vol. 5589:
Fiber Optic Sensor Technology and Applications III
Michael A. Marcus; Brian Culshaw; John P. Dakin, Editor(s)

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