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Proceedings Paper

Optical fiber biosensor based on localized surface plasmon resonance in gold nanoparticles
Author(s): Kotaro Kajikawa; Keita Mitsui
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Paper Abstract

We developed a label-free, highly sensitive, real time, and micrometer-sized optical fiber biosensor without using any attenuated total reflection (ATR) optics. The sensor is based on the localized surface plasmon resonance (LPR) in gold nanoparticles. The gold nanoparitlces show a large absorption band at around 520 nm due to LPR, which is quite sensitive to the environment around the nanoparticles. Thus change of the refractive index of the ambient medium around the nanoparticles or overcoating a thin dielectric layer on the particles results in a red-shift of the absorption band and change of the absorption intensity. This paper reports a novel optical fiber biosensor that is constructed at the endface of the optical fiber. The fiber probe is consisting of gold nanoparticles that plays as a transducer, where ligand is coated. The return light intensity from the fiber probe is changed by the adsorption of the biomolecules that has affinity to the ligand. The sensitivity was evaluated to be 10 pg/mm2 (2x10-5 RIU) with an LED light, which is compatible with the conventional surface plasmon resonance biosensors that use the ATR optics.

Paper Details

Date Published: 29 December 2004
PDF: 8 pages
Proc. SPIE 5593, Nanosensing: Materials and Devices, (29 December 2004); doi: 10.1117/12.571166
Show Author Affiliations
Kotaro Kajikawa, Tokyo Institute of Technology (Japan)
PRESTO/Japan Science and Technology Agency (Japan)
Keita Mitsui, PRESTO/Japan Science and Technology Agency (Japan)

Published in SPIE Proceedings Vol. 5593:
Nanosensing: Materials and Devices
M. Saif Islam; Achyut K. Dutta, Editor(s)

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