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Proceedings Paper

Sequence-specific DNA sensing based on silicon nanowires
Author(s): Zhiyong Li; Xuema Li; Theodore I. Kamins; Yong Chen; R. Stanley Williams
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Paper Abstract

Highly sensitive, sequence-specific and label-free DNA sensors were demonstrated by monitoring the electronic conductance of silicon nanowires with chemically bonded single stranded (ss) DNA or peptide nucleic acid (PNA) probe molecules. For a 12-mer oligonucleotide, tens of pM of target ss-DNA in solution was recognized when the complementary DNA oligonucleotide probe was attached to the SiNW surfaces. In contrast, ss-DNA samples of 1000x concentration with single base mismatch only produce a weak signal due to nonspecific binding.

Paper Details

Date Published: 29 December 2004
PDF: 7 pages
Proc. SPIE 5593, Nanosensing: Materials and Devices, (29 December 2004); doi: 10.1117/12.570817
Show Author Affiliations
Zhiyong Li, Hewlett-Packard Labs. (United States)
Xuema Li, Hewlett-Packard Labs. (United States)
Theodore I. Kamins, Hewlett-Packard Labs. (United States)
Yong Chen, Univ. of California/Los Angeles (United States)
R. Stanley Williams, Hewlett-Packard Labs. (United States)

Published in SPIE Proceedings Vol. 5593:
Nanosensing: Materials and Devices
M. Saif Islam; Achyut K. Dutta, Editor(s)

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