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Proceedings Paper

Mesospaced surface for DNA microarray and other applications
Author(s): Bong Jin Hong; Chang Ok Kim; Soon Jin Oh; Joon Won Park
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Paper Abstract

We have studied ways to control density as well as spacing among functional groups. In particular, we observed that use of aziridine for the surface hyperbranching polymerization yielded extremely high surface density of primary amine that is useful for the immobilization of molecules of biological relevance such as oligo DNA. Also, an employment of dendrons of appropriate molecular architecture provided mesospacing among the reactive functional groups. The spacings was expected to guarantee the freedom of the biological macromolecules so that their properties are close to that in solution in spite of the confinement in the two dimensional world. We demonstrated that this was the case for oligonucleotide microarrays.

Paper Details

Date Published: 29 December 2004
PDF: 15 pages
Proc. SPIE 5593, Nanosensing: Materials and Devices, (29 December 2004); doi: 10.1117/12.569695
Show Author Affiliations
Bong Jin Hong, Pohang Univ. of Science and Technology (South Korea)
Chang Ok Kim, Pohang Univ. of Science and Technology (South Korea)
Soon Jin Oh, Pohang Univ. of Science and Technology (South Korea)
Joon Won Park, Pohang Univ. of Science and Technology (South Korea)

Published in SPIE Proceedings Vol. 5593:
Nanosensing: Materials and Devices
M. Saif Islam; Achyut K. Dutta, Editor(s)

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