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Proceedings Paper

1H NMR analysis of complexation of hydrotropic agents nicotinamide and caffeine with aromatic biologically active molecules in aqueous solution
Author(s): Anastasia O. Lantushenko; Yulia V. Mukhina; Kyrill A. Veselkov; David B. Davies; Alexei N. Veselkov
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Paper Abstract

NMR spectroscopy has been used to elucidate the molecular mechanism of solubilization action of hydrotropic agents nicotinamide (NA) and caffeine (CAF). Hetero-association of NA with riboflavine-mononucleotide (FMN) and CAF with low soluble in aqueous solution synthetic analogue of antibiotic actinomycin D, actinocyl-bis-(3-dimethylaminopropyl) amine (Actill), has been investigated by 500 MHz 1H NMR spectroscopy. Concentration and temperature dependences of proton chemical shifts have been analysed in terms of a statistical-thermodynamic model of indefinite self- and heteroassociation of aromatic molecules. The obtained results enable to conclude that NA-FMN and CAF-Actill intermolecular complexes are mainly stabilized by the stacking interactions of the aromatic chromophores. Hetero-association of the investigated molecules plays an important role in solubilization of aromatic drugs by hydrotropic agents nicotinamide and caffeine.

Paper Details

Date Published: 20 July 2004
PDF: 6 pages
Proc. SPIE 5507, XVI International Conference on Spectroscopy of Molecules and Crystals, (20 July 2004); doi: 10.1117/12.569621
Show Author Affiliations
Anastasia O. Lantushenko, Sevastopol National Technical Univ. (Ukraine)
Yulia V. Mukhina, Sevastopol National Technical Univ. (Ukraine)
Kyrill A. Veselkov, Sevastopol National Technical Univ. (Ukraine)
David B. Davies, Univ. of London (United Kingdom)
Alexei N. Veselkov, Sevastopol National Technical Univ. (Ukraine)


Published in SPIE Proceedings Vol. 5507:
XVI International Conference on Spectroscopy of Molecules and Crystals
Galyna O. Puchkovska; Tatiana A. Gavrilko; Olexandr I. Lizengevich, Editor(s)

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