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Proceedings Paper

Gated cardiac SPECT in rodents using a dedicated SPECT system: X-SPECT
Author(s): Thor Vandehei; J. Li; Koji Iwata; Bradley E. Patt; G. Caravaglia; Neal E. Hartsough; Bruce H. Hasegawa; Benjamin M. W. Tsui
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Paper Abstract

Cardiac function is an important physiological parameter in preclinical studies. Nuclear cardiac scans are a standard of care for patients with suspected coronary artery occlusions and can assess perfusion and other physiological functions via the injection of radiotracers. In addition, correlated acquisition of nuclear images with electrocardiogram (ECG) signals can provide myocardial dynamics, which can be used to assess the wall motion of the heart. We have implemented this nuclear cardiology technique into a microSPECT/CT system, which provides sub-millimeter resolution in SPECT and co-registered high resolution CT anatomical maps. Radionuclide detection is synchronized with the R-wave of the cardiac cycle and separated into 16 time bins using an ECG monitor and triggering device for gating. Images were acquired with a 12.5 x 12.5 cm2 small field of view pixilated NaI(Tl) detector, using a pinhole collimator. In this pilot study, rats (N = 5) were injected with 99mTc-Sestamibi, a tracer of myocardium, and anesthetized for imaging. Reconstructed 4-D images (3D plus timing) were computed using an Ordered Subset Expectation Maximization (OSEM) algorithm. The measured perfusion, wall motion, and ejection fractions for the rats matched well with results reported by other researchers using alternative methods. This capability will provide a new and powerful tool to preclinical researchers for assessing cardiac function.

Paper Details

Date Published: 26 October 2004
PDF: 6 pages
Proc. SPIE 5541, Penetrating Radiation Systems and Applications VI, (26 October 2004); doi: 10.1117/12.567145
Show Author Affiliations
Thor Vandehei, Gamma Medica, Inc. (United States)
J. Li, Gamma Medica, Inc. (United States)
Koji Iwata, Gamma Medica, Inc. (United States)
Bradley E. Patt, Gamma Medica, Inc. (United States)
G. Caravaglia, Gamma Medica, Inc. (United States)
Neal E. Hartsough, Photon Imaging, Inc. (United States)
Bruce H. Hasegawa, Univ. of California/San Francisco (United States)
Benjamin M. W. Tsui, Johns Hopkins Univ. (United States)

Published in SPIE Proceedings Vol. 5541:
Penetrating Radiation Systems and Applications VI
F. Patrick Doty; Richard C. Schirato; H. Bradford Barber; Hans Roehrig, Editor(s)

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