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Proceedings Paper

Characterization of the hydration state of pharmaceuticals by variable-temperature diffuse-reflectance infrared spectroscopy
Author(s): Frank M. Wasacz; Scott W. Strand; David E. Bugay; Kenneth R. Morris
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Paper Abstract

The characterization of hydrates is exceedingly important for pharmaceuticals since the state of hydration of a drug can effect its solubility, dissolution rate, bioavailability, chemical stability, and the physical stability of subsequent dosage forms. In addition, the United States Food and Drug Administration concerns about the above issue make complete characterization of hydrates a necessary part of investigative new drug filings. A Collector TM Diffuse Reflectance accessory fitted with a controlled Environmental Chamber was used to study drug formulations under varying temperature and humidity conditions.

Paper Details

Date Published: 1 March 1992
PDF: 2 pages
Proc. SPIE 1575, 8th Intl Conf on Fourier Transform Spectroscopy, (1 March 1992); doi: 10.1117/12.56324
Show Author Affiliations
Frank M. Wasacz, Spectra-Tech, Inc. (United States)
Scott W. Strand, Spectra-Tech, Inc. (United States)
David E. Bugay, Bristol-Myers Squibb Co. (United States)
Kenneth R. Morris, Bristol-Myers Squibb Co. (United States)

Published in SPIE Proceedings Vol. 1575:
8th Intl Conf on Fourier Transform Spectroscopy

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