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Proceedings Paper

Molecular tissue mapping by FTIR microspectroscopy
Author(s): John A. Reffner; Frank M. Wasacz
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Paper Abstract

Determining the molecular chemical composition of human tissue is important to understanding its biochemistry. Variation in a tissue's biochemistry may result from normal changes in tissue type or from artifacts, which range from foreign materials trapped in tissue to the degeneration products associated with disease. While pathologists use light microscopy to identify abnormal areas of tissue, they can obtain only limited molecular information through staining or fluorescence methods. However, when microscopy and infrared spectroscopy are combined, they produce a powerful technique for probing the chemistry of different areas of tissue samples. In addition, the integration of FT-IR microanalysis with a scanning stage produces compositional maps that directly link molecular structure and morphology.

Paper Details

Date Published: 1 March 1992
PDF: 4 pages
Proc. SPIE 1575, 8th Intl Conf on Fourier Transform Spectroscopy, (1 March 1992); doi: 10.1117/12.56323
Show Author Affiliations
John A. Reffner, Spectra-Tech, Inc. (United States)
Frank M. Wasacz, Spectra-Tech, Inc. (United States)

Published in SPIE Proceedings Vol. 1575:
8th Intl Conf on Fourier Transform Spectroscopy
Herbert Michael Heise; Ernst Heiner Korte; Heinz W. Siesler, Editor(s)

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