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Proceedings Paper

Newt limb regeneration studied with synchrotron micro-CT
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Paper Abstract

Newts are the most developed vertebrates which retain the ability as adults to regenerate missing limbs; they are, therefore, of great interest in terms understanding how such regeneration could be triggered in mammals. In this study, synchrotron microCT was used to study bone microstructure in control forelimbs and in forelimbs regenerated for periods from 37 to 85 days. The bone microstructure in newts has been largely neglected, and interesting patterns within the original bone and in the regenerating arm and hand are described. Periosteal bone formation in the regenerating arm and finger bones, delayed ossification of carpal (but not metacarpal) bones and the complex microstructure of the original carpal bones are areas where microCT reveals detail of particular interest.

Paper Details

Date Published: 26 October 2004
PDF: 9 pages
Proc. SPIE 5535, Developments in X-Ray Tomography IV, (26 October 2004); doi: 10.1117/12.560472
Show Author Affiliations
Stuart R. Stock, Northwestern Univ. (United States)
Konstantin I. Ignatiev, Northwestern Univ. (United States)
Hans-Georg Simon, Northwestern Univ. (United States)
Francesco De Carlo, Argonne National Lab. (United States)

Published in SPIE Proceedings Vol. 5535:
Developments in X-Ray Tomography IV
Ulrich Bonse, Editor(s)

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