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Proceedings Paper

Lung imaging of laboratory rodents in vivo
Author(s): Dianna D. Cody; Dawn Cavanaugh; Roger E. Price; Belinda Rivera; Gregory Gladish; Elizabeth Travis
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Paper Abstract

We have been acquiring respiratory-gated micro-CT images of live mice and rats for over a year with our General Electric (formerly Enhanced Vision Systems) hybrid scanner. This technique is especially well suited for the lung due to the inherent high tissue contrast. Our current studies focus on the assessment of lung tumors and their response to experimental agents, and the assessment of lung damage due to chemotherapy agents. We have recently installed a custom-built dual flat-panel cone-beam CT scanner with the ability to scan laboratory animals that vary in size from mice to large dogs. A breath-hold technique is used in place of respiratory gating on this scanner. The objective of this pilot study was to converge on scan acquisition parameters and optimize the visualization of lung damage in a mouse model of fibrosis. Example images from both the micro-CT scanner and the flat-panel CT scanner will be presented, as well as preliminary data describing spatial resolution, low contrast resolution, and radiation dose parameters.

Paper Details

Date Published: 26 October 2004
PDF: 10 pages
Proc. SPIE 5535, Developments in X-Ray Tomography IV, (26 October 2004); doi: 10.1117/12.559727
Show Author Affiliations
Dianna D. Cody, Univ. of Texas M. D. Anderson Cancer Ctr. (United States)
Dawn Cavanaugh, Univ. of Texas M. D. Anderson Cancer Ctr. (United States)
Roger E. Price, Univ. of Texas M. D. Anderson Cancer Ctr. (United States)
Belinda Rivera, Univ. of Texas M. D. Anderson Cancer Ctr. (United States)
Gregory Gladish, Univ. of Texas M. D. Anderson Cancer Ctr. (United States)
Elizabeth Travis, Univ. of Texas M. D. Anderson Cancer Ctr. (United States)


Published in SPIE Proceedings Vol. 5535:
Developments in X-Ray Tomography IV
Ulrich Bonse, Editor(s)

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