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Proceedings Paper

Manipulation of DNA molecules using optical techniques for optically assisted DNA computing
Author(s): Yusuke Ogura; Fumika Sumiyama; Takashi Kawakami; Jun Tanida
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Paper Abstract

DNA computing is an interesting computational paradigm utilizing reactive nature of DNA. The DNA computing realizes massively parallel computation because a large number of DNAs are processed in parallel. However, the computational functionality is restricted by the number of DNA molecules and DNA reactions that can be employed. As a new computational scheme, we are studying optically assisted DNA computing, which utilizes flexibility in generating light fields and parallelism of DNA reactions. Toward the goal, we experimentally verified methods for translating DNA molecules and controlling DNA reactions locally by using optical techniques. An optical manipulation method with VCSEL array sources is applied to translate DNA. We succeeded to translate two DNA clusters, which consisted of many DNA molecules attached to particles, in different directions simultaneously by switching the emission pattern of the VCSEL array. The reaction of DNA is controlled by irradiating with a laser beam. Experimental results demonstrated that double stranded DNAs, which were immobilized to the surface of a particle or a substrate, were denaturated at a resolution of several micrometer. The methods make possible to deal with a set of DNAs selectively and are useful in executing flexible operations for computing.

Paper Details

Date Published: 8 October 2004
PDF: 9 pages
Proc. SPIE 5515, Nanoengineering: Fabrication, Properties, Optics, and Devices, (8 October 2004); doi: 10.1117/12.559241
Show Author Affiliations
Yusuke Ogura, Osaka Univ. (Japan)
Fumika Sumiyama, Osaka Univ. (Japan)
Takashi Kawakami, Osaka Univ. (Japan)
Jun Tanida, Osaka Univ. (Japan)

Published in SPIE Proceedings Vol. 5515:
Nanoengineering: Fabrication, Properties, Optics, and Devices
Elizabeth A. Dobisz; Louay A. Eldada, Editor(s)

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