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Proceedings Paper

Stochastic dynamics of the cardiovascular system
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Paper Abstract

The human cardiovascular system (CVS), responsible for the delivery of nutrients and removal of waste products to/from the entire body, is a highly complex system involving many control mechanisms. Signals derived from the CVS are inherently difficult to analyse because they are noisy, time-varying, and of necessarily limited duration. The application of techniques drawn from nonlinear science has, however, yielded many insights into the nature of the CVS, and has provided strong evidence for a large degree of determinism in the way it functions. Yet there is compelling evidence that random fluctuations (noise) also play an essential role. There are at least five oscillatory processes of widely differing frequency involved in the blood distribution. The evidence for them, and their probable physiological origins, are discussed. Interactions between some of the processes can give rise to modulation and synchronization phenomena, very similar to those observed in classical oscillators in many areas of physics. The extent to which the CVS can be modelled as a stochastic nonlinear dynamical system is reviewed, and future research directions and possible applications based on this perception are considered.

Paper Details

Date Published: 25 May 2004
PDF: 15 pages
Proc. SPIE 5467, Fluctuations and Noise in Biological, Biophysical, and Biomedical Systems II, (25 May 2004); doi: 10.1117/12.555849
Show Author Affiliations
Peter V. E. McClintock, Lancaster Univ. (United Kingdom)
Aneta Stefanovska, Univ. of Ljubljana (Slovenia)
Lancaster Univ. (United Kingdom)

Published in SPIE Proceedings Vol. 5467:
Fluctuations and Noise in Biological, Biophysical, and Biomedical Systems II
Derek Abbott; Sergey M. Bezrukov; Andras Der; Angel Sanchez, Editor(s)

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