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Proceedings Paper

Nanoshell bioconjugates for integrated imaging and therapy of cancer
Author(s): Christopher H. Loo; Min-Ho Lee; Leon R. Hirsch; Jennifer L. West; Naomi J. Halas; Rebekah A. Drezek
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Paper Abstract

Currently, separate diagnostic and therapeutic modalities are required for the diagnosis and treatment of cancer. In many cases, the present standard of care requires invasive surgical procedures and/or other treatments associated with significant side effect profiles, high cost, and poor clinical outcome. A single technology with dual diagnostic/therapeutic capabilities would potentially yield significant savings in the time and cost associated with diagnosing and treating many cancers. In this paper, we discuss gold nanoshell bioconjugates and their role in the development of an integrated cancer imaging and therapy application. Nanoshells are a novel class of nanomaterials that have unique properties including continuous and broad wavelength tunability, far greater scattering and absorption coefficients, increased chemical stability, and improved biocompatibility. Here, we describe the development of an integrated cancer imaging and therapy application using near-infrared (NIR) gold nanoshell bioconjugates.

Paper Details

Date Published: 16 June 2004
PDF: 4 pages
Proc. SPIE 5327, Plasmonics in Biology and Medicine, (16 June 2004); doi: 10.1117/12.553184
Show Author Affiliations
Christopher H. Loo, Rice Univ. (United States)
Min-Ho Lee, Rice Univ. (United States)
Leon R. Hirsch, Rice Univ. (United States)
Jennifer L. West, Rice Univ. (United States)
Naomi J. Halas, Rice Univ. (United States)
Rebekah A. Drezek, Rice Univ. (United States)

Published in SPIE Proceedings Vol. 5327:
Plasmonics in Biology and Medicine
Tuan Vo-Dinh; Zygmunt Gryczynski; Joseph R. Lakowicz, Editor(s)

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