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Proceedings Paper

Probing feature selectivity of neurons in primary visual cortex with natural stimuli
Author(s): Tatyana Sharpee; Hiroki Sugihara; A. V. Kurgansky; S. Rebrik; M. P. Stryker; Kenneth D. Miller
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Paper Abstract

One way to characterize neural feature selectivity is to model the response probability as a nonlinear function of the output of a set of linear filters applied to incoming signals. Traditionally these linear filters are measured by probing neurons with correlated Gaussian noise ensembles and calculating correlation functions between incoming signals and neural responses. It is also important to derive these filters in response to natural stimuli, which have been shown to have strongly non-Gaussian spatiotemporal correlations. An information-theoretic method has been proposed recently for reconstructing neural filters using natural stimuli in which one looks for filters whose convolution with the stimulus ensemble accounts for the maximal possible part of the overall information carried the sequence of neural responses. Here we give a first-time demonstration of this method on real neural data, and compare responses of neurons in cat primary visual cortex driven with natural stimuli, noise ensembles, and moving gratings. We show that the information-theoretic method achieves the same quality of filter reconstruction for natural stimuli as that of well-established white-noise methods. Major parameters of neural filters derived from noise ensembles and natural stimuli, as well as from moving gratings are consistent with one another. We find that application of the reverse correlation method to natural stimuli ensembles leads to significant distortions in filters for a majority of studied cells with non-zero reverse-correlation filter.

Paper Details

Date Published: 25 May 2004
PDF: 11 pages
Proc. SPIE 5467, Fluctuations and Noise in Biological, Biophysical, and Biomedical Systems II, (25 May 2004); doi: 10.1117/12.548513
Show Author Affiliations
Tatyana Sharpee, Univ. of California/San Francisco (United States)
Hiroki Sugihara, Univ. of California/San Francisco (United States)
A. V. Kurgansky, Univ. of California/San Francisco (United States)
S. Rebrik, Univ. of California/San Francisco (United States)
M. P. Stryker, Univ. of California/San Francisco (United States)
Kenneth D. Miller, Univ. of California/San Francisco (United States)

Published in SPIE Proceedings Vol. 5467:
Fluctuations and Noise in Biological, Biophysical, and Biomedical Systems II
Derek Abbott; Sergey M. Bezrukov; Andras Der; Angel Sanchez, Editor(s)

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