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Proceedings Paper

The study of learning in networks of purified-cultured rat hippocampus neurons
Author(s): Xiangning Li; Wei Zhou; Ni Sun; Qingming Luo
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Paper Abstract

Learning is crucial for brain functioning, especially for hippocampus. To understand the basis of physiological information processing of hippocampus, we developed the networks of purified-cultured rat hippocampus neurons on a planar 60-microelectrode array MEA. We describe how these networks are prepared, their structure, and the forms of spontaneous activity they exhibit. We stimulate the network at a low frequency until a desired predefined response is observed 50- 10 msec after a stimulus, at which point the stimulus is stopped for 5 min. Repeated cycles of this procedure ultimately lead to the desired response being directly elicited by the stimulus. These results demonstrate that there is learning in networks composed of purified-cultured hippocampus neurons.

Paper Details

Date Published: 8 December 2003
PDF: 7 pages
Proc. SPIE 5254, Third International Conference on Photonics and Imaging in Biology and Medicine, (8 December 2003); doi: 10.1117/12.546574
Show Author Affiliations
Xiangning Li, Huazhong Univ. of Science and Technology (China)
Wei Zhou, Huazhong Univ. of Science and Technology (China)
Ni Sun, Huazhong Univ. of Science and Technology (China)
Qingming Luo, Huazhong Univ. of Science and Technology (China)


Published in SPIE Proceedings Vol. 5254:
Third International Conference on Photonics and Imaging in Biology and Medicine
Qingming Luo; Valery V. Tuchin; Min Gu; Lihong V. Wang, Editor(s)

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