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Proceedings Paper

Fluorescent imaging the characteristic of Pyro-2DG uptake in the normal tissue using the Cryo-Imager
Author(s): Zhihong Zhang; Dana Blessington; Gang Zheng; Qingming Luo; Britton Chance
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Paper Abstract

In the previous study, we have proved that Pyro-2DG could be trapped and accumulated in the tumor. The fluorescent signal of Pyro-2DG has high correlation with the redox ratio. To further study the extrinsic probe Pyro-2DG, the characteristic of Pyro-2DG uptake by the liver tissue of rats and the distribution of Pyro-2DG in various tissues were detected using the Cryo-Imager. The result indicated that Pyro-2DG uptake by the liver resulted in the metabolic state shift towards an increased concentration of oxidized electron carriers and it completely recovered after 24hrs. Pyro-2DG with infusion injection could avoid the oxidized damage of the normal tissue induced by Pyro-2DG uptake. The distribution of Pyro-2DG in various normal tissues indicated that Pyro-2DG could be as a tumor special near infrared ray (NIR) probe besides the hepatic tumor and lymph system tumor.

Paper Details

Date Published: 8 December 2003
PDF: 6 pages
Proc. SPIE 5254, Third International Conference on Photonics and Imaging in Biology and Medicine, (8 December 2003); doi: 10.1117/12.546193
Show Author Affiliations
Zhihong Zhang, Huazhong Univ. of Science and Technology (China)
Univ. of Pennsylvania (United States)
Dana Blessington, Univ. of Pennsylvania (United States)
Gang Zheng, Univ. of Pennsylvania (United States)
Qingming Luo, Huazhong Univ. of Science and Technology (China)
Britton Chance, Univ. of Pennsylvania (United States)


Published in SPIE Proceedings Vol. 5254:
Third International Conference on Photonics and Imaging in Biology and Medicine

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