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Proceedings Paper

The mechanism of PDT-induced apoptosis
Author(s): Xiongwei Cai; Timon Cheng-Yi Liu; Xin-Min Ding; Ying Gu; Fan-Guang Liu; Song-Hao Liu
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Paper Abstract

Photodynamic therapy (PDT) can induce apoptosis in many cancer cells in vitro and in tumors in vivo. Cells become more oxidation with PDT, and maintain differentiation and proliferation, go apoptosis and necrosis with the increase of reactive oxygen species (ROS) concentration. ROS can induce apoptosis through mitochondria by inhibiting respiration chain or oxidative phosphorylation or damaging mitochondrial membrane. ROS can initiate apoptosis through endoplamic reticulum(ER) by opening Ca2+ channel or starting unfold protein response (UPR). ROS can also induce apoptosis through Golgi by producing ganglioside GD3 by use of ceramide, which induces apoptosis by activating caspase-3, JNK and p38 MAPK. It can also induce apoptosis by activating Bip (mitochondria-dependant) or preocaspase-12 (mitochondria- independent) or inhibiting protein synthesizing. There are so complicated cross-talking among different signal pathways or organnells that we think PDT-induced apoptosis is mediated by multiplex pathways and excessive levels in a refined network.

Paper Details

Date Published: 8 December 2003
PDF: 6 pages
Proc. SPIE 5254, Third International Conference on Photonics and Imaging in Biology and Medicine, (8 December 2003); doi: 10.1117/12.546157
Show Author Affiliations
Xiongwei Cai, South China Normal Univ. (China)
Chinese PLA General Hospital (China)
Timon Cheng-Yi Liu, South China Normal Univ. (China)
Huazhong Univ. of Science and Technology (China)
Xin-Min Ding, Chinese PLA General Hospital (China)
Ying Gu, Chinese PLA General Hospital (China)
Fan-Guang Liu, Chinese PLA General Hospital (China)
Song-Hao Liu, South China Normal Univ. (China)

Published in SPIE Proceedings Vol. 5254:
Third International Conference on Photonics and Imaging in Biology and Medicine
Qingming Luo; Valery V. Tuchin; Min Gu; Lihong V. Wang, Editor(s)

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