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Proceedings Paper

Simultaneous imaging of intrinsic optical signals and cerebral vessel responses during cortical spreading depression in rats
Author(s): Pengcheng Li; Shangbin Chen; Weihua Luo; Qingming Luo
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Paper Abstract

Cortical spreading depression (CSD) is an important disease model for migraine and cerebral ischemia. We investigated the spatio-temporal characteristics of the intrinsic optical signals (IOS) at 570 nm and the cerebral blood vessel responses during CSD simultaneously by optical reflectance imaging in vivo. The CSD were induced by pinprick in 10 α-chloralose/urethane anesthetized Sprague-Dawley rats. A four-phasic IOS response was observed at pial arteries and parenchymal sites in all experimental animals and an initial slight pial arteries dilation (21.5%±13.6%) and constriction (-4.2%±3.5%) precedes the dramatic dilation (69.2%±26.1%) of pial arterioles was recorded. Our experimental results show a high correlation (r = 0.89±0.025) between the IOS response and the diameter changes of the cerebral blood vessels during CSD in rats.

Paper Details

Date Published: 8 December 2003
PDF: 5 pages
Proc. SPIE 5254, Third International Conference on Photonics and Imaging in Biology and Medicine, (8 December 2003); doi: 10.1117/12.546133
Show Author Affiliations
Pengcheng Li, Huazhong Univ. of Science and Technology (China)
Shangbin Chen, Huazhong Univ. of Science and Technology (China)
Weihua Luo, Huazhong Univ. of Science and Technology (China)
Qingming Luo, Huazhong Univ. of Science and Technology (China)


Published in SPIE Proceedings Vol. 5254:
Third International Conference on Photonics and Imaging in Biology and Medicine
Qingming Luo; Valery V. Tuchin; Min Gu; Lihong V. Wang, Editor(s)

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