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Proceedings Paper

Dye-enhanced selective photothermal laser-tissue interaction and photodynamic therapy in combination with immunoadjuvant for cancer treatment
Author(s): Wei R. Chen; Kenneth Eugene Bartels D.V.M.; Jinghai Sun; Hong Liu; Robert E. Nordquist; Mladen Korbelik
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Paper Abstract

Immunoadjuvants have been used to stimulate host immune responses. However, immunoadjuvants alone have not been very successful in treating metastatic tumors. Following the principle of combined therapy in AIDS treatment and in combination chemotherapy, immunoadjuvants have been used in conjunction with other treatment modalities. The current study is an attempt to use both selective photothermal and selective photochemical interactions to accompany a new immunoadjuvant in the treatment of metastatic tumors. The immunoadjuvant, glycated chitosan (GC), has been shown in the previous studies to be effective in inducing immune responses when combined with the treatment of laser irradiation after the intratumoral injection of indocyanine green solution. When glycated chitosan was used with photodynamic therapy (PDT), the treatment effect was significantly increased. Specifically, when glycated chitosan was injected peritumorally after Photofrin-based PDT treatment of EMT6 mammary sarcoma in mice, the tumor-free rate of the treated mice was increased from 38% to 75% using 1.5% GC solution. In mTHPC-based PDT treatment of Line-1 lung adenocarcinoma in mice, the tumor-free rates of treated mice reached 38% while PDT alone did not result in any tumor free mouse. The combination of the immunoadjuvant and selective photophysical interaction may become an effective method to treat tumors with an induced anti-tumor immunity.

Paper Details

Date Published: 8 December 2003
PDF: 9 pages
Proc. SPIE 5254, Third International Conference on Photonics and Imaging in Biology and Medicine, (8 December 2003); doi: 10.1117/12.546093
Show Author Affiliations
Wei R. Chen, Univ. of Central Oklahoma (United States)
Univ. of Oklahoma (United States)
Kenneth Eugene Bartels D.V.M., Oklahoma State Univ. (United States)
Jinghai Sun, British Columbia Cancer Agency (Canada)
Hong Liu, Univ. of Oklahoma (United States)
Robert E. Nordquist, Wound Healing of Oklahoma, Inc. (United States)
Mladen Korbelik, British Columbia Cancer Agency (Canada)

Published in SPIE Proceedings Vol. 5254:
Third International Conference on Photonics and Imaging in Biology and Medicine
Qingming Luo; Valery V. Tuchin; Min Gu; Lihong V. Wang, Editor(s)

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