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Proceedings Paper

Femtosecond relativistic electron beam triggered early bioradical events
Author(s): Yann A. Gauduel; Sven Fritzler; Abdeslem Hallou; Y. Glinec; Victor Malka
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Paper Abstract

With the recent advent of table-top terawatt Ti:Sa laser amplifier systems, laser plasma interactions provide high-energy, femtosecond electron bunches, which might conjecture direct observation of radiation events in media of biological interest. We report on the first femtolysis studies using such laser produced relativistic electron pulses in the 2.5-15 MeV range. A real-time observation of elementary radical events is performed on water molecules and media containing an important disulfide biomolecule. The primary yield of a reducing radical produced in clusters of excitation-ionisation events (spurs) has been determined at t~3.5 10-12 s. These data provide important information about the initial energy loss and spatial distribution of early radical events. Femtolysis studies devoted to a disulfide biomolecule is noteworthy as it is the first time that a primary ionisation event can be controlled by an ultrafast radical anion formation in the prethermal regime. This innovating domain foreshadows the development of new applications in radiobiology (microdosimetry at the nanometric scale). In the near future, electron femtolysis studies would clearly enhance the understanding of radiation-induced damages in biological confined spaces (aqueous groove of DNA and protein pockets).

Paper Details

Date Published: 8 September 2004
PDF: 11 pages
Proc. SPIE 5463, Femtosecond Laser Applications in Biology, (8 September 2004); doi: 10.1117/12.545408
Show Author Affiliations
Yann A. Gauduel, Lab. d'Optique Appliquee, CNRS, ENSTA, and Ecole Polytechnique (France)
Sven Fritzler, Lab. d'Optique Appliquee, CNRS, ENSTA, and Ecole Polytechnique (France)
Abdeslem Hallou, Lab. d'Optique Appliquee, CNRS, ENSTA, and Ecole Polytechnique (France)
Y. Glinec, Lab. d'Optique Appliquee, CNRS, ENSTA, and Ecole Polytechnique (France)
Victor Malka, Lab. d'Optique Appliquee, CNRS, ENSTA, and Ecole Polytechnique (France)


Published in SPIE Proceedings Vol. 5463:
Femtosecond Laser Applications in Biology
Sigrid Avrillier; Jean-Michel Tualle, Editor(s)

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