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Proceedings Paper

Kinetics of camptothecin hydrolysis determined by PCA and FA analysis of fluorescence spectra
Author(s): Stefan Kruszewski; Ryszard Siuda; Blanka Ziomkowska; Michal Cyrankiewicz
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Paper Abstract

The application of fluorescence spectroscopy methods in investigations of camptothecin (CPT) is presented in this paper. Fluorescence of CPT enables one to follow the process of hydrolysis, i.e. the process of converting the biologically active lactone form into inactive carboxylate. The fluorescence spectra of CPT recorded during the hydrolysis were analysed using Principale Component Analysis and Factor Analysis. The results obtained on the basis of fluorescence spectra analysis are compared with HPLC data.

Paper Details

Date Published: 21 November 2003
PDF: 9 pages
Proc. SPIE 5259, 13th Polish-Czech-Slovak Conference on Wave and Quantum Aspects of Contemporary Optics, (21 November 2003); doi: 10.1117/12.545163
Show Author Affiliations
Stefan Kruszewski, Ludwik Rydygier Medical Univ. (Poland)
Univ. of Technology and Agriculture (Poland)
Ryszard Siuda, Univ. of Technology and Agriculture (Poland)
Blanka Ziomkowska, Univ. of Technology and Agriculture (Poland)
Michal Cyrankiewicz, Univ. of Technology and Agriculture (Poland)


Published in SPIE Proceedings Vol. 5259:
13th Polish-Czech-Slovak Conference on Wave and Quantum Aspects of Contemporary Optics
Jerzy Nowak; Marek Zajac; Jan Masajada, Editor(s)

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