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Proceedings Paper

Nonlinear-optical spectroscopy for tissue diagnostics: application to laser ablation of skin tissue
Author(s): Asatur A. Lalayan
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Paper Abstract

Tissue nonlinear spectroscopy has been investigated as potential method for the monitoring of the laser ablation process of skin tissues. Nonlinear optical phenomenon of second harmonic generation that effectively occurs when femtosecond-picosecond duration pulses of laser irradiation passed through collagen contained layer is used to monitor photothermal processes. The samples of skin tissues were irradiated by continuous wave Nd:YAG laser and then were tested by probing picosecond beam. The change in amplitude of nonlinear optical response at ablated area of sample has been revealed. As result of laser ablation in 2mm of diameter area the SHG nonlinear signal was increased approximately two times. Polarization dependence of second harmonic generation has been studied, comparing with another nonlinear process - two-photon fluorescence in samples of ordered biotissue.

Paper Details

Date Published: 8 September 2004
PDF: 6 pages
Proc. SPIE 5463, Femtosecond Laser Applications in Biology, (8 September 2004); doi: 10.1117/12.544473
Show Author Affiliations
Asatur A. Lalayan, Yerevan State Univ. (Armenia)

Published in SPIE Proceedings Vol. 5463:
Femtosecond Laser Applications in Biology
Sigrid Avrillier; Jean-Michel Tualle, Editor(s)

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