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Proceedings Paper

Metallic nanostructures for plasmonic sensors using surface-enhanced fluorescence and Raman detection
Author(s): Fei Yan; Musundi B. Wabuyele; Guy D. Griffin; Tuan Vo-Dinh
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Paper Abstract

We present the fabrication and characterization of silver island films with SiO2 coatings for application in plasmonic sensors based on surface-enhanced fluorescence and Raman detection. The emission spectral properties of goat anti-mouse immunoglobulin (IgG) F(ab')2 labeled with one or two fluorescein residues were examined on substrates with metallic silver islands. The self-quenching of fluorescein emission was mostly eliminated when this antibody fragment was held 60-90 Å from the surface of metallic silver islands, and our preliminary experiments demonstrated an 8-fold emission intensity increase. Similar surfaces were also examined for surface-enhanced Raman analysis of Rhodamine 123, a potential drug for photodynamic therapy.

Paper Details

Date Published: 16 June 2004
PDF: 7 pages
Proc. SPIE 5327, Plasmonics in Biology and Medicine, (16 June 2004); doi: 10.1117/12.542455
Show Author Affiliations
Fei Yan, Oak Ridge National Lab. (United States)
Musundi B. Wabuyele, Oak Ridge National Lab. (United States)
Guy D. Griffin, Oak Ridge National Lab. (United States)
Tuan Vo-Dinh, Oak Ridge National Lab. (United States)

Published in SPIE Proceedings Vol. 5327:
Plasmonics in Biology and Medicine
Tuan Vo-Dinh; Zygmunt Gryczynski; Joseph R. Lakowicz, Editor(s)

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