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Proceedings Paper

Multiclassifier information fusion methods for microarray pattern recognition
Author(s): Jerome J. Braun; Yan Glina; Nicholas Judson; Rachel Herzig-Marx
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Paper Abstract

This paper addresses automatic recognition of microarray patterns, a capability that could have a major significance for medical diagnostics, enabling development of diagnostic tools for automatic discrimination of specific diseases. The paper presents multiclassifier information fusion methods for microarray pattern recognition. The input space partitioning approach based on fitness measures that constitute an a-priori gauging of classification efficacy for each subspace is investigated. Methods for generation of fitness measures, generation of input subspaces and their use in the multiclassifier fusion architecture are presented. In particular, two-level quantification of fitness that accounts for the quality of each subspace as well as the quality of individual neighborhoods within the subspace is described. Individual-subspace classifiers are Support Vector Machine based. The decision fusion stage fuses the information from mulitple SVMs along with the multi-level fitness information. Final decision fusion stage techniques, including weighted fusion as well as Dempster-Shafer theory based fusion are investigated. It should be noted that while the above methods are discussed in the context of microarray pattern recognition, they are applicable to a broader range of discrimination problems, in particular to problems involving a large number of information sources irreducible to a low-dimensional feature space.

Paper Details

Date Published: 12 April 2004
PDF: 12 pages
Proc. SPIE 5434, Multisensor, Multisource Information Fusion: Architectures, Algorithms, and Applications 2004, (12 April 2004); doi: 10.1117/12.541062
Show Author Affiliations
Jerome J. Braun, MIT Lincoln Lab. (United States)
Yan Glina, MIT Lincoln Lab. (United States)
Nicholas Judson, MIT Lincoln Lab. (United States)
Rachel Herzig-Marx, MIT Lincoln Lab. (United States)

Published in SPIE Proceedings Vol. 5434:
Multisensor, Multisource Information Fusion: Architectures, Algorithms, and Applications 2004
Belur V. Dasarathy, Editor(s)

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