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Proceedings Paper

Dynamic imaging of tumor vasculature in rodents: carbogen-induced contrast enhancement
Author(s): Kenneth T. Kotz; Konstantinos S. Kalogerakis; William N. Boenig; Khalid Amin; Gregory W. Faris
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Paper Abstract

We have studied the dynamic changes in tissue vasculature following the inhalation of hyperoxic gasses in rodents as a model for optical breast cancer detection. We have used a CW apparatus to measure the near infrared (NIR) optical properties of animal models immersed in a liquid tissue phantom. By looking at the transmission of different wavelengths in the NIR, we were able to qualitatively observe changes in blood oxygenation following the inhalation of different mixtures of CO2 and O2. These changes enhanced the image contrast between cancerous tissue and normal tissues of the rodents. The oxygenation dynamics of the tumors, following inhalation of the hyperoxic gases, exhibited differences from surrounding tissues in both the magnitude of the observed signal change and the dynamic response.

Paper Details

Date Published: 13 July 2004
PDF: 5 pages
Proc. SPIE 5312, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV, (13 July 2004); doi: 10.1117/12.538888
Show Author Affiliations
Kenneth T. Kotz, SRI International (United States)
Konstantinos S. Kalogerakis, SRI International (United States)
William N. Boenig, SRI International (United States)
Khalid Amin, SRI International (United States)
Gregory W. Faris, SRI International (United States)

Published in SPIE Proceedings Vol. 5312:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV
Brian Jet-Fei Wong; Nikiforos Kollias; Kenton W. Gregory; Henry Hirschberg; Reza S. Malek; Abraham Katzir; David S. Robinson; Kenneth Eugene Bartels; Eugene A. Trowers; Werner T.W. de Riese; Lawrence S. Bass; Lloyd P. Tate; Steen J. Madsen; Keith D. Paulsen; Karen M. McNally-Heintzelman, Editor(s)

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